database / immune
Daptomycin
also known as Cubicin
Skeletal structure drawn from the computed atomic coordinates in PubChem CID 21585658. Carbons are implicit vertices, hydrogens on carbon suppressed. Every atom sits where PubChem placed it.
Sequence
Primary structure not characterised in the public record.
A cyclic lipopeptide made by non-ribosomal synthesis, carrying a decanoyl tail and several non-proteinogenic residues.
Molecular data
| molecular formula | C72H101N17O26 |
|---|---|
| molecular weight | 1620.7 Da (PubChem) |
| computed backbone mass | not characterised |
| length | not characterised |
| net charge (pH 7.4) | not characterised |
| mean hydropathy | not characterised |
| half-life | not characterised |
| delivery route | intravenous |
| PubChem CID | 21585658 |
| PDB | not characterised |
| UniProt parent | not characterised |
Mechanism
Calcium-dependent insertion into Gram-positive membranes, causing depolarisation.
Reported targets: bacterial membrane
Experimental structure
No experimental structure deposited in the PDB. A predicted fold is not a structure, so nothing is drawn.
Reported effects
Each row is an outcome described in the literature indexed for this peptide.
| reported outcome | where it appears |
|---|---|
| bactericidal activity against Gram-positive organisms | The double-edged sword of daptomycin: a case of daptomycin-induced eosinophi… Oxford medical case reports 2026 |
Registered trials
| NCT | title | status | phase |
|---|---|---|---|
| NCT00295178 | Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipe | COMPLETED | PHASE4 |
| NCT00490737 | Safety Study to Evaluate Daptomycin in Non-infected Adults Who Are Either on Hemodialysis or | COMPLETED | PHASE1 |
| NCT03250104 | Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infectio | COMPLETED | — |
| NCT00967941 | Vancomycin and Daptomycin Plus Cefazolin for Preoperative Vascular Surgery Prophylaxis | COMPLETED | — |
| NCT06191601 | Interest in Probabilistic Antibiotic Therapy With Broad-spectrum Beta-lactams in Orthopedic | UNKNOWN | — |
Literature (8)
The double-edged sword of daptomycin: a case of daptomycin-induced eosinophilic pneumonia — Oxford medical case reports 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42583159 · DOI 10.1093/omcr/omag146
Saturated fatty acids enhance daptomycin activity in a Fak-dependent manner in enterococci — Microbiology (Reading, England) 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42560741 · DOI 10.1099/mic.0.001751
Effects of Cholesterol and Solution pH on Daptomycin-bilayer Interactions — The Journal of membrane biology 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42667401 · DOI 10.1007/s00232-026-00400-8
Treatment outcomes of daptomycin- and vancomycin-resistant <i>Enterococcus faecium</i> bloodstream infection — JAC-antimicrobial resistance 2026
ObjectivesAmong patients with daptomycin-resistant and vancomycin-resistant Enterococcus faecium bloodstream infection (BSI), the optimal definitive therapy is uncertain. We estimated the dose effect of daptomycin (≥[dose redacted] versus 8 to MethodsAdults with VRE BSI who received linezolid or daptomycin ≥[dose redacted] were included. Post hoc daptomycin MICs were determined by Sensititre broth microdilution (BMD), and episodes with MIC ≥[dose redacted] were analyzed. The primary outcome was 28-day in-hospital mortality.ResultsAmong 130 patients with daptomycin-resistant VRE BSI, 110 received daptomycin and 20 received linezolid. Within the daptomycin group, 28-day mortality was 55.1% (43/78) with daptomycin 8 to P = 0.03]. Among isolates with daptomycin MIC = [dose redacted], 28-day mortality was 54.9% in patients treated with daptomycin 8 to P = 0.04); no benefit was seen for MIC ≥[dose redacted] (P > 0.99). 28-day mortali…
open access ↗ · PMID 42290912 · DOI 10.1093/jacamr/dlag108
Daptomycin Overcomes <i>Listeria monocytogenes</i> Persister Cells Through Strain-Dependent Efficacy and clpP-Mediated Stress Response — Infection and drug resistance 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42609602 · DOI 10.2147/idr.s569234
Development of Linezolid and Daptomycin resistance in Vancomycin Resistant Enterococcus Faecium During Antibiotic Treatment — FEMS microbiology letters 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42644769 · DOI 10.1093/femsle/fnag097
Daptomycin-Induced Eosinophilic Pneumonia in a Patient Treated for MRSA Foot Infection: A Case Report — Journal of the American Podiatric Medical Association 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42496338 · DOI 10.3390/japma116040049
Population pharmacokinetics of daptomycin in patients with haematological malignancies and vancomycin-resistant Enterococcus bloodstream infections — International journal of antimicrobial agents 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42637177 · DOI 10.1016/j.ijantimicag.2026.107974
The mechanism, illustrated
Not memed yet.
33 of the 100 indexed peptides have one. See which →
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