database / hormone
Leuprolide
also known as leuprorelin, Lupron
Skeletal structure drawn from the computed atomic coordinates in PubChem CID 657181. Carbons are implicit vertices, hydrogens on carbon suppressed. Every atom sits where PubChem placed it.
Sequence
Primary structure not characterised in the public record.
A GnRH analogue with pyroglutamate at the N-terminus and D-leucine at position 6.
Molecular data
| molecular formula | C59H84N16O12 |
|---|---|
| molecular weight | 1209.4 Da (PubChem) |
| computed backbone mass | not characterised |
| length | not characterised |
| net charge (pH 7.4) | not characterised |
| mean hydropathy | not characterised |
| half-life | not characterised |
| delivery route | subcutaneous, intramuscular |
| PubChem CID | 657181 |
| PDB | not characterised |
| UniProt parent | not characterised |
Mechanism
GnRH receptor agonist; continuous exposure downregulates the receptor and suppresses gonadotropins.
Reported targets: GnRHR
Experimental structure
No experimental structure deposited in the PDB. A predicted fold is not a structure, so nothing is drawn.
Reported effects
Each row is an outcome described in the literature indexed for this peptide.
| reported outcome | where it appears |
|---|---|
| gonadotropin suppression | Pulmonary alveolar proteinosis diagnosed during leuprorelin acetate therapy … BMC pulmonary medicine 2026 |
| oncology outcomes in trials | GnRH Agonists and Antagonists in IVF/ICSI Cycles of PCOS Women: A Network Me… Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2026 |
Registered trials
| NCT | title | status | phase |
|---|---|---|---|
| NCT04500743 | Role of Suppression of Endometriosis With Progestins Before IVF-ET | COMPLETED | NA |
| NCT02678520 | Clinical Trial Comparing 3-D RT vs. IMRT in Post- Prostatectomy Prostate Cancer Patients | WITHDRAWN | PHASE2 |
| NCT01320735 | Observational Program to Assess Use of Intermittent Adjuvant Deprivation Therapy With Leupro | COMPLETED | — |
| NCT02903368 | Neoadjuvant And Adjuvant Abiraterone Acetate + Apalutamide Prostate Cancer Undergoing Prosta | COMPLETED | PHASE2 |
| NCT01081873 | Study to Document Treatment Patterns and to Evaluate Leuprolide and Alternative Therapeutic | COMPLETED | — |
Literature (8)
Pulmonary alveolar proteinosis diagnosed during leuprorelin acetate therapy for ovarian endometrioma: a case report — BMC pulmonary medicine 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42469731 · DOI 10.1186/s12890-026-04507-5
GnRH Agonists and Antagonists in IVF/ICSI Cycles of PCOS Women: A Network Meta-Analysis — Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42152207 · DOI 10.29271/jcpsp.2026.05.654
Therapeutic efficacy of leuprorelin acetate combined with rhGH in girls with ICPP and Its impact on body height and secondary sexual characteristics — Pakistan journal of medical sciences 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42369946 · DOI 10.12669/pjms.42.6.14211
Linzagolix versus leuprorelin in Japanese women with uterine leiomyomas: a phase 3, randomized, active-controlled, non-inferiority trial — Human reproduction (Oxford, England) 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42406777 · DOI 10.1093/humrep/deag106
Efficacy and safety of goserelin vs. leuprolide in premenopausal breast cancer patients receiving adjuvant endocrine therapy: A retrospective cohort study — Medwave 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42617170 · DOI 10.5867/medwave.2026.07.3216
Comparative Study of Subcutaneous 6-Month Versus Intramuscular 3-Month Leuprorelin Use in Central Precocious Puberty — Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 41962547 · DOI 10.1055/a-2771-0527
The effectiveness of relugolix compared with leuprorelin for preoperative therapy before laparoscopic myomectomy: a randomized controlled noninferiority study (MyLacR study) — Fertility and sterility 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 41581744 · DOI 10.1016/j.fertnstert.2026.01.011
Enzalutamide in biochemically recurrent prostate cancer: key findings from subsequent analyses of EMBARK and their implications in clinical practice — Future oncology (London, England) 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42333826 · DOI 10.1080/14796694.2026.2676559
The mechanism, illustrated
Not memed yet.
33 of the 100 indexed peptides have one. See which →
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